Active substances: Hydroxyzine
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Protein binding, in particular, has a significant impact on passage of drugs into breastmilk, where highly protein bound drugs are less likely to be transferred into breastmilk.
Because sertraline has a large volume of distribution, much of the drug in the body is outside systemic circulation.
Investigators have examined infant cytochrome P 450 genotype to assess impact on drug metabolism. Berle et al. Sertraline was not detected in the serum of any of the drug-exposed infants.
The sample presented by Berle et al. This supports the contention by both Weissman et al. METHODS Analysis of Current Literature Given the varied methodology and small sample sizes in the available literature, we sought to examine the direction and strength of association between maternal and infant sertraline levels via secondary research based on a literature review of existing studies.
We identified 13 studies that reported 142 sertraline levels for breastfed infants whose mothers were taking sertraline Altshuler et al. Of these 142, 123 86. Wisner, Perel, and Blumer Wisner et al.
Stowe et al. A nucleophilic substitution is used to introduce the sidechain.
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