Active substances: Orlistat
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Long-term Despite a higher incidence of breast cancer amongst those taking orlistat in early, pooled clinical trial data—the analysis of which delayed FDA review of orlistat —a two-year study published in 1999 found similar rates between orlistat and placebo 0.
A multivitamin tablet containing vitamins A, D, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat.
When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose.
The primary route of elimination is through the feces.